The maker of the injectable insulin
Victoza (aka/ liraglutide), Danish company Novo Nordisk, presented
test results at the 9th Annual International Diabetes Federation Western
Pacific Region Congress in Kyoto, Japan, on November 27, 2012, that
reflected that Victoza is more likely to enable Type 2 diabetics to
achieve lower AIC levels during a 26-week period (testing at 12 weeks,
20 weeks and 26 weeks) than does oral Sitagliptin (Januvia) and
injectable Exenatide
in people with Type 2 diabetes. The study results indicated that the
AIC desired levels were lower than 7.0 during that testing period for
the participants in the study.
Victoza, in conjunction with diet and a recommended exercise
program, is an injection used only in persons with Type 2 diabetes (not
recommended for use for Type 1 diabetes). A side benefit of Victoza has
been a slowing of the emptying of the stomach, which may decrease
appetite and create some weight loss in certain patients.
Sitagliptin,
commonly referred to as “Januvia,” is made by Merck & Company, and
is an oral diabetic drug. Long-standing studies have shown that this
oral medication
for treatment in Type 2 diabetes has fewer side effects than any number
of other drugs used in the treatment of Type 2 diabetes. Less weight
gain and fewer incidents of hypoglycemia have been found in most
studies.
Thứ Bảy, 15 tháng 12, 2012
Mayo Study Claims Metformin Helps Ovarian Cancer
While diabetes is a common fatal disease in the United States,
ovarian cancer is quickly growing to be another one to look out for as
well. Now there may be a chance to help cure one with one simple pill.
A study by the Mayo Clinic has shown that the diabetic insulin-sensitizing drug Metformin has shown improvement in patients who are suffering from ovarian cancer. Patients with both diabetes and ovarian cancer and took the drug had a better survival rate than those who did not. The drug also helped to slow the growth of and prevent tumors.
The findings of this new study can be used by researchers to study other medications as well to find out if any of them can be used to treat other diseases.
According to the American Cancer Society, about 22,280 new cases of ovarian cancer were diagnosed this year and about 15,500 will succumb to it in the United States. A woman has a 1 in 71 chance of developing invasive ovarian cancer and the same woman has a 1 in 95 chance of dying from it. That is a large amount, to large in fact and now there is a potential drug that can help to decrease that number. Metformin is a drug that is widely used for diabetes, to help manage and treat the disease. However, in previous studies it has shown great promise for various types of cancers, the latest being ovarian cancer.
Sanjeev Kumar, M.B.B.S., a Mayo Clinic gynecologic oncology fellow said, “Our study demonstrated improved survival in women with ovarian cancer that were taking metformin. The results are encouraging, but as with any retrospective study, many factors cannot be controlled for us to say if there is a direct cause and effect. Rather, this is further human evidence for a potential beneficial effect of a commonly used drug which is relatively safe in humans. These findings should provide impetus for prospective clinical trials in ovarian cancer.”
Researchers are hoping that this new information will help pave a way for using metformin to cure large-scale randomized trials of ovarian cancer. Researchers believe that there is a great need for developing a cure since ovarian cancer has such a high mortality rate annually and this is just one more step in the right direction.
A study by the Mayo Clinic has shown that the diabetic insulin-sensitizing drug Metformin has shown improvement in patients who are suffering from ovarian cancer. Patients with both diabetes and ovarian cancer and took the drug had a better survival rate than those who did not. The drug also helped to slow the growth of and prevent tumors.
The findings of this new study can be used by researchers to study other medications as well to find out if any of them can be used to treat other diseases.
According to the American Cancer Society, about 22,280 new cases of ovarian cancer were diagnosed this year and about 15,500 will succumb to it in the United States. A woman has a 1 in 71 chance of developing invasive ovarian cancer and the same woman has a 1 in 95 chance of dying from it. That is a large amount, to large in fact and now there is a potential drug that can help to decrease that number. Metformin is a drug that is widely used for diabetes, to help manage and treat the disease. However, in previous studies it has shown great promise for various types of cancers, the latest being ovarian cancer.
Here is a breakdown of the study:
For the study, 61 patients with ovarian cancer (taking metformin) and 178 with ovarian cancer (not taking metformin) were compared by researchers. About 67 percent of the patients who were taking the drug survived after five years, they were compared against the 47 percent who did not take the drug. Factors such as: the severity of the cancer, type of chemotherapy, quality of surgery and body mass index all weighed in as well. The results for the entire study showed that those who had ovarian cancer and took metformin were four times likelier to survive than those who were not taking the medication.Sanjeev Kumar, M.B.B.S., a Mayo Clinic gynecologic oncology fellow said, “Our study demonstrated improved survival in women with ovarian cancer that were taking metformin. The results are encouraging, but as with any retrospective study, many factors cannot be controlled for us to say if there is a direct cause and effect. Rather, this is further human evidence for a potential beneficial effect of a commonly used drug which is relatively safe in humans. These findings should provide impetus for prospective clinical trials in ovarian cancer.”
Researchers are hoping that this new information will help pave a way for using metformin to cure large-scale randomized trials of ovarian cancer. Researchers believe that there is a great need for developing a cure since ovarian cancer has such a high mortality rate annually and this is just one more step in the right direction.
Diabetes, Cashews & Dementia
What do cashews and dementia have in common? They are commonly linked
with diabetes. The first as a preventative aid and the second a
byproduct of uncontrolled diabetes.
According to TopNews, “A new study by the researchers from Universities of Montreal, Canada and de Yaounde Cameroun has indicated towards the effectiveness of the cashew seed extract against diabetes.”
Pierre Haddad is a professor of pharmacology in Montreal who indicated, “Cashew seeds extract have effectively stimulated the absorption of blood sugar by muscle cells, among all the extracts tested.”
The reason the research is significant is because the cashew is a natural and sustainable resource that can be used in cost effective treatment of diabetes. Obviously more research will be needed, but the use of cashews in the care of diabetes may be viewed as another positive in the ongoing quest to find treatments and an ultimate cure for diabetes.
Haddad is quoted by TopNews as saying, “Our study validates the traditional use of cashew tree products in diabetes and points to some of its natural components that can serve to create new oral therapies.”
Cashews come from a fruit known as cashew apples. The apple is small and typically rots within 24 hours of picking. The research extended to the apple, the leaf and the bark of the cashew apple trees. Cashews are said to be anti-inflammatory and can be used to control the blood sugar levels in those living with diabetes.
Meanwhile, TopNews also reported, “Mayo Clinic’s Florida campus and the University of California have conducted a research on whether dementia varies with people having diabetes or not. Blood samples of 211 people with dementia and 403 without dementia were collected to compare the ratio of two dissimilar types of amyloid beta proteins in blood.”
It has been said that Alzheimer’s is a form of diabetes because insulin levels are extremely low in patients with Alzheimer’s. However, the report suggests that dementia in diabetes is different than Alzheimers, “The findings show that people who have diabetes are more likely to get affected by vascular disease, which affects blood flow in brain vessels causing dementia. People who suffer from dementia without diabetes are affected by brain plaque deposits, which are generally found in Alzheimer patients,” said TopNews.
The study was published in the Archives of Neurology. TopNews reports, “Those having dementia without diabetes can cure the same by taking high levels of vitamin E in their meals, as Vitamin E guards the brain against oxidative stress, which causes Alzheimer.”
To avoid dementia in adults the findings suggest that, “The intake of four antioxidants — vitamin E, vitamin C, beta carotene and flavanoids — can improve the function of the memory.”
In diabetes, dementia is often the result of vessel damage between the heart and brain. By understanding the cause medical practitioners may be able to better guard against the instance of dementia by assisting their diabetic patients with information and medication that may prove helpful.
These two stories continue to point to the wide variety of tools researchers are using in order to gain a better understanding of diabetes and how it affects patients. Similarly they are also working to use every available resource to better the lives of their patients.
The overall care of those with diabetes continues to improve with each passing year and research findings like these assist in advancing the cause of care.
According to TopNews, “A new study by the researchers from Universities of Montreal, Canada and de Yaounde Cameroun has indicated towards the effectiveness of the cashew seed extract against diabetes.”
Pierre Haddad is a professor of pharmacology in Montreal who indicated, “Cashew seeds extract have effectively stimulated the absorption of blood sugar by muscle cells, among all the extracts tested.”
The reason the research is significant is because the cashew is a natural and sustainable resource that can be used in cost effective treatment of diabetes. Obviously more research will be needed, but the use of cashews in the care of diabetes may be viewed as another positive in the ongoing quest to find treatments and an ultimate cure for diabetes.
Haddad is quoted by TopNews as saying, “Our study validates the traditional use of cashew tree products in diabetes and points to some of its natural components that can serve to create new oral therapies.”
Cashews come from a fruit known as cashew apples. The apple is small and typically rots within 24 hours of picking. The research extended to the apple, the leaf and the bark of the cashew apple trees. Cashews are said to be anti-inflammatory and can be used to control the blood sugar levels in those living with diabetes.
Meanwhile, TopNews also reported, “Mayo Clinic’s Florida campus and the University of California have conducted a research on whether dementia varies with people having diabetes or not. Blood samples of 211 people with dementia and 403 without dementia were collected to compare the ratio of two dissimilar types of amyloid beta proteins in blood.”
It has been said that Alzheimer’s is a form of diabetes because insulin levels are extremely low in patients with Alzheimer’s. However, the report suggests that dementia in diabetes is different than Alzheimers, “The findings show that people who have diabetes are more likely to get affected by vascular disease, which affects blood flow in brain vessels causing dementia. People who suffer from dementia without diabetes are affected by brain plaque deposits, which are generally found in Alzheimer patients,” said TopNews.
The study was published in the Archives of Neurology. TopNews reports, “Those having dementia without diabetes can cure the same by taking high levels of vitamin E in their meals, as Vitamin E guards the brain against oxidative stress, which causes Alzheimer.”
To avoid dementia in adults the findings suggest that, “The intake of four antioxidants — vitamin E, vitamin C, beta carotene and flavanoids — can improve the function of the memory.”
In diabetes, dementia is often the result of vessel damage between the heart and brain. By understanding the cause medical practitioners may be able to better guard against the instance of dementia by assisting their diabetic patients with information and medication that may prove helpful.
These two stories continue to point to the wide variety of tools researchers are using in order to gain a better understanding of diabetes and how it affects patients. Similarly they are also working to use every available resource to better the lives of their patients.
The overall care of those with diabetes continues to improve with each passing year and research findings like these assist in advancing the cause of care.
A Guide To Sugar Alcohols
There is a lot of buzz going around the internet about low-calorie
sweeteners. Some say they are okay to use and others say to stay away
from them. Sugar alcohols are just one of the low-calorie sweeteners
that many are buzzing about.
Right now in our world, dieters and diabetics are looking for the next best thing when it comes to being able to sweeten their foods without the worry of eating sugar or taking in large portions of calories. Sugar alcohols give the capability to keep both of those things away.
You will find sugar alcohols in many products that you buy on a regular basis, such as:
Right now in our world, dieters and diabetics are looking for the next best thing when it comes to being able to sweeten their foods without the worry of eating sugar or taking in large portions of calories. Sugar alcohols give the capability to keep both of those things away.
What Are Sugar Alcohols?
If you’ve picked up a package of “sugar-free” gum or an ice cream container that said “no sugar added”, chances are you’ve already seen some sugar alcohols. You just didn’t realize it. Of course, most packages do not say sugar alcohols. There are many names for sugar alcohols. Here are a few of them:- Isomalt
- Maltitol
- Sorbitol
- Erythiritol
- Mannitol
- Hydrogenated Starch Hydrolysates
- Xylitol
You will find sugar alcohols in many products that you buy on a regular basis, such as:
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